Assay Detail
Functional
CHEMBL1067625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of Chinese hamster PC43-10 cells expressing human RFC after 96 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | PC43-10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590985 | TALOTREXIN | 2.0 | 1 | 8.89 |
| CHEMBL590740 | — | — | 1 | - |
| CHEMBL605580 | — | — | 1 | - |
| CHEMBL601009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590985 | TALOTREXIN | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL590740 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL605580 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL601009 | — | IC50 | > | 1000.0 | nM | - |