Assay Detail
Functional
CHEMBL1067628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of Chinese hamster RT16 cells expressing human FRalpha in presence of 200 nM folic acid after 96 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | RT16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.06 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590985 | TALOTREXIN | 2.0 | 1 | 6.06 |
| CHEMBL590740 | — | — | 1 | - |
| CHEMBL605580 | — | — | 1 | - |
| CHEMBL601009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590985 | TALOTREXIN | IC50 | = | 864.0 | nM | 6.06 |
| CHEMBL590740 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL605580 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL601009 | — | IC50 | > | 1000.0 | nM | - |