Assay Detail
Binding
CHEMBL1067751
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Inhibition of PTPalpha expressed in Escherichia coli BL21 (DE3) after 10 mins by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 2A activator (CHEMBL2505) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.47 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602231 | — | — | 1 | 4.64 |
| CHEMBL599646 | — | — | 1 | 4.30 |
| CHEMBL598217 | — | — | 1 | - |
| CHEMBL603479 | — | — | 1 | - |
| CHEMBL598832 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602231 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL599646 | — | IC50 | = | 49700.0 | nM | 4.30 |
| CHEMBL598217 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL603479 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL598832 | — | IC50 | > | 100000.0 | nM | - |