Assay Detail
Binding
CHEMBL1067804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of piperazine-indole p38 alpha MAP kinase inhibitors with improved pharmacokinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.61 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605134 | — | — | 1 | 8.22 |
| CHEMBL514201 | TALMAPIMOD | 2.0 | 1 | 8.05 |
| CHEMBL591217 | — | — | 1 | 8.05 |
| CHEMBL600470 | — | — | 1 | 7.62 |
| CHEMBL600583 | — | — | 1 | 7.54 |
| CHEMBL601666 | — | — | 1 | 7.33 |
| CHEMBL605790 | — | — | 1 | 7.32 |
| CHEMBL601452 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605134 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL514201 | TALMAPIMOD | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL591217 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL600470 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL600583 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL601666 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL605790 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL601452 | — | IC50 | = | 183.0 | nM | 6.74 |