Assay Detail
Binding
CHEMBL1067914
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Inhibition of human factor 10a by microplate spectrophotometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.00 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596107 | — | — | 1 | 9.37 |
| CHEMBL593604 | — | — | 1 | 8.85 |
| CHEMBL479863 | — | — | 1 | 8.64 |
| CHEMBL605310 | — | — | 1 | 8.52 |
| CHEMBL595663 | — | — | 1 | 8.48 |
| CHEMBL595710 | — | — | 1 | 8.47 |
| CHEMBL605507 | — | — | 1 | 8.39 |
| CHEMBL594308 | — | — | 1 | 8.31 |
| CHEMBL593315 | — | — | 1 | 8.24 |
| CHEMBL593603 | — | — | 1 | 8.02 |
| CHEMBL594532 | — | — | 1 | 7.92 |
| CHEMBL593326 | — | — | 1 | 7.92 |
| CHEMBL596106 | — | — | 1 | 7.46 |
| CHEMBL594487 | — | — | 1 | 6.06 |
| CHEMBL604884 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596107 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL593604 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL479863 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL605310 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL595663 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL595710 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL605507 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL594308 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL593315 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL593603 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL594532 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL593326 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL596106 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL594487 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL604884 | — | IC50 | = | 4000.0 | nM | 5.40 |