Assay Detail
Functional
CHEMBL1067953
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Induction of differentiation of human HL60 promyelocytes into monocytes after 4 days by NBT reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 9.33 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607373 | — | — | 1 | 9.70 |
| CHEMBL594078 | — | — | 1 | 9.52 |
| CHEMBL596532 | — | — | 1 | 9.40 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607373 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL594078 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL596532 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL846 | CALCITRIOL | EC50 | = | 2.0 | nM | 8.70 |