Assay Detail
Binding
CHEMBL1067992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9 cells by DELFIA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465130 | — | — | 1 | 8.00 |
| CHEMBL602703 | — | — | 1 | 8.00 |
| CHEMBL464510 | — | — | 1 | 7.70 |
| CHEMBL591924 | — | — | 1 | 7.70 |
| CHEMBL602704 | — | — | 1 | 7.70 |
| CHEMBL602905 | — | — | 1 | 7.70 |
| CHEMBL600604 | — | — | 1 | 7.52 |
| CHEMBL612137 | — | — | 1 | 7.40 |
| CHEMBL600632 | — | — | 1 | 6.68 |
| CHEMBL600603 | — | — | 1 | 6.44 |
| CHEMBL600398 | — | — | 1 | 6.07 |
| CHEMBL603082 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465130 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL602703 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL464510 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL591924 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL602704 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL602905 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL600604 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL612137 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL600632 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL600603 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL600398 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL603082 | — | IC50 | = | 1200.0 | nM | 5.92 |