Compound Detail
CHEMBL600398
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Basic Information
| ChEMBL ID | CHEMBL600398 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JKCHAENVNKVZKN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
530.5
MW (Da)
5.95
ALogP
7
HBA
2
HBD
94.6
PSA (Ų)
0.26
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.07 | 6.07 | 860.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 860.0 | nM | 6.07 | Inhibition of recombinant GST-fused VEGFR2 expressed in baculovirus infected Sf9... | 20071170 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20071170 | 10.1016/j.bmcl.2009.12.099 | Vascular endothelial growth factor receptor 2 | 1 |
| 20071170 | 10.1016/j.bmcl.2009.12.099 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine