Assay Detail
Binding
CHEMBL1068016
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of L type calcium channel alpha-1c/alpha-2-delta-1/beta-1b expressed in HEK293 cells in presence of -100 mV holding potential by whole-cell patch clamp method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b (CHEMBL3988638) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.12 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603465 | — | — | 1 | 6.21 |
| CHEMBL596942 | — | — | 1 | 5.99 |
| CHEMBL599217 | — | — | 1 | 5.74 |
| CHEMBL599402 | — | — | 1 | 5.37 |
| CHEMBL597788 | — | — | 1 | 5.18 |
| CHEMBL599404 | — | — | 1 | 5.07 |
| CHEMBL597783 | — | — | 1 | 4.96 |
| CHEMBL604710 | Z160 | 2.0 | 1 | 4.91 |
| CHEMBL597756 | — | — | 1 | 4.75 |
| CHEMBL597585 | — | — | 1 | 4.71 |
| CHEMBL608740 | — | — | 1 | 4.52 |
| CHEMBL598812 | — | — | 1 | 4.00 |
| CHEMBL598592 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603465 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL596942 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL599217 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL599402 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL597788 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL599404 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL597783 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL604710 | Z160 | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL597756 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL597585 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL608740 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL598812 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL598592 | — | IC50 | = | 106000.0 | nM | - |