Assay Detail
Binding
CHEMBL1068017
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Inhibition of L-type calcium channel alpha-1c/alpha-2-delta-1/beta-1b expressed in HEK293 cells by FLIPR method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b (CHEMBL3988638) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.44 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605965 | — | — | 1 | 5.96 |
| CHEMBL597969 | — | — | 1 | 5.96 |
| CHEMBL598392 | — | — | 1 | 5.85 |
| CHEMBL589285 | — | — | 1 | 5.85 |
| CHEMBL606175 | — | — | 1 | 5.80 |
| CHEMBL599408 | — | — | 1 | 5.80 |
| CHEMBL597788 | — | — | 1 | 5.75 |
| CHEMBL597970 | — | — | 1 | 5.60 |
| CHEMBL598598 | — | — | 1 | 5.54 |
| CHEMBL598603 | — | — | 1 | 5.54 |
| CHEMBL597782 | — | — | 1 | 5.51 |
| CHEMBL599217 | — | — | 1 | 5.46 |
| CHEMBL599625 | — | — | 1 | 5.42 |
| CHEMBL597585 | — | — | 1 | 5.21 |
| CHEMBL599404 | — | — | 1 | 5.21 |
| CHEMBL599403 | — | — | 1 | 5.17 |
| CHEMBL599402 | — | — | 1 | 5.16 |
| CHEMBL596946 | — | — | 1 | 5.13 |
| CHEMBL597572 | — | — | 1 | 5.10 |
| CHEMBL597775 | — | — | 1 | 5.07 |
| CHEMBL605769 | — | — | 1 | 5.03 |
| CHEMBL599015 | — | — | 1 | 5.02 |
| CHEMBL598990 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605965 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL597969 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL598392 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL589285 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL606175 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL599408 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL597788 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL597970 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL598598 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL598603 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL597782 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL599217 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL599625 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL597585 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL599404 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL599403 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL599402 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL596946 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL597572 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL597775 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL605769 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL599015 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL598990 | — | IC50 | = | 10000.0 | nM | 5.00 |