Assay Detail
Binding
CHEMBL1068174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to guinea pig adenosine A2A receptor
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.04 | 6.64 |
| IC50 | 1 | 5.93 | 5.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | 3.0 | 1 | 6.64 |
| CHEMBL440115 | FK453 | 1.0 | 1 | 5.93 |
| CHEMBL589549 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52333 | ROLOFYLLINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL440115 | FK453 | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL589549 | — | Ki | = | 3750.0 | nM | 5.43 |