Assay Detail
Binding
CHEMBL1068436
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Inhibition of human 17beta-HSD3 expressed in HeLa cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 3 (CHEMBL4234) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.64 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589158 | — | — | 1 | 8.82 |
| CHEMBL590129 | — | — | 1 | 8.52 |
| CHEMBL589396 | — | — | 1 | 8.10 |
| CHEMBL589156 | — | — | 1 | 8.00 |
| CHEMBL592758 | — | — | 1 | 7.70 |
| CHEMBL590378 | — | — | 1 | 7.57 |
| CHEMBL592043 | — | — | 1 | 7.52 |
| CHEMBL590379 | — | — | 1 | 7.33 |
| CHEMBL605407 | — | — | 1 | 7.23 |
| CHEMBL590376 | — | — | 1 | 7.06 |
| CHEMBL601700 | — | — | 1 | 7.04 |
| CHEMBL605082 | — | — | 1 | 7.03 |
| CHEMBL590131 | — | — | 1 | 7.02 |
| CHEMBL600114 | — | — | 1 | 7.00 |
| CHEMBL589883 | — | — | 1 | 7.00 |
| CHEMBL104679 | — | — | 1 | 6.72 |
| CHEMBL592042 | — | — | 1 | 6.70 |
| CHEMBL589155 | — | — | 1 | 6.70 |
| CHEMBL19240 | — | — | 1 | 6.68 |
| CHEMBL590377 | — | — | 1 | 6.64 |
| CHEMBL591811 | — | — | 1 | 6.62 |
| CHEMBL590613 | — | — | 1 | 6.50 |
| CHEMBL592761 | — | — | 1 | 6.38 |
| CHEMBL590130 | — | — | 1 | 6.00 |
| CHEMBL593427 | — | — | 1 | 6.00 |
| CHEMBL609568 | — | — | 1 | 6.00 |
| CHEMBL593424 | — | — | 1 | 6.00 |
| CHEMBL593904 | — | — | 1 | 6.00 |
| CHEMBL325841 | — | — | 1 | 6.00 |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589158 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL590129 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL589396 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL589156 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL592758 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL590378 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL592043 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL590379 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL605407 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL590376 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL601700 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL605082 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL590131 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL600114 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL589883 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL104679 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL592042 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL589155 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL19240 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL590377 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL591811 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL590613 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL592761 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL593904 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL12208 | HYMECROMONE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL325841 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL593424 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL609568 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL593427 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL590130 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL592760 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL607808 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL592524 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL601481 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL592759 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL592757 | — | IC50 | = | 10000.0 | nM | 5.00 |