Assay Detail
Binding
CHEMBL1068568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Noncompetitive inhibition of yeast Hst2 using NAD+ substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase HST2 (CHEMBL5933) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Identification and characterization of novel sirtuin inhibitor scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.35 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595128 | — | — | 1 | 5.92 |
| CHEMBL594863 | — | — | 1 | 5.60 |
| CHEMBL82949 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595128 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL594863 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL82949 | — | Ki | = | 30000.0 | nM | 4.52 |