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Assay Detail

CHEMBL1068620

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Functional
Antioxidant activity assessed as hypochlorous acid scavenging activity by fluorescent rhodamine formation assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and antioxidant properties of new chromone derivatives.
Gomes A, Neuwirth O, Freitas M, Couto D, Ribeiro D, Figueiredo AG, Silva AM, Seixas RS, Pinto DC, Tomé AC, Cavaleiro JA, Fernandes E, Lima JL.
Bioorg Med Chem (2009) 17 : 7218 -7226
PubMed 19781949 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.44 5.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL594248 1 5.84
CHEMBL608678 1 5.77
CHEMBL134342 THIOCTIC ACID 1 5.71
CHEMBL593336 1 5.64
CHEMBL596552 1 5.60
CHEMBL593303 1 5.33
CHEMBL594247 1 4.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL594248 IC50 = 1450.0 nM 5.84
CHEMBL608678 IC50 = 1700.0 nM 5.77
CHEMBL134342 THIOCTIC ACID IC50 = 1950.0 nM 5.71
CHEMBL593336 IC50 = 2290.0 nM 5.64
CHEMBL596552 IC50 = 2490.0 nM 5.60
CHEMBL593303 IC50 = 4670.0 nM 5.33
CHEMBL594247 IC50 = 67200.0 nM 4.17