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Assay Detail

CHEMBL1068645

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Functional
Antiproliferative activity against human HuH7 cells after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Huh-7 (CHEMBL614039)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and evaluation of functionalized isoindigos as antiproliferative agents.
Wee XK, Yeo WK, Zhang B, Tan VB, Lim KM, Tay TE, Go ML.
Bioorg Med Chem (2009) 17 : 7562 -7571
PubMed 19783149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.89 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL409450 6BIO 1 5.21
CHEMBL595433 1 5.12
CHEMBL607196 1 5.09
CHEMBL595191 1 5.05
CHEMBL604278 1 4.92
CHEMBL604077 1 4.88
CHEMBL604266 1 4.88
CHEMBL594018 1 4.88
CHEMBL607535 MEISOINDIGO 1 4.74
CHEMBL594032 1 4.72
CHEMBL594713 1 4.70
CHEMBL515155 ISOINDIGO 1 4.54
CHEMBL594849 1 -
CHEMBL594611 1 -
CHEMBL595210 1 -
CHEMBL608404 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL409450 6BIO IC50 = 6200.0 nM 5.21
CHEMBL595433 IC50 = 7500.0 nM 5.12
CHEMBL607196 IC50 = 8200.0 nM 5.09
CHEMBL595191 IC50 = 9000.0 nM 5.05
CHEMBL604278 IC50 = 12000.0 nM 4.92
CHEMBL604077 IC50 = 13200.0 nM 4.88
CHEMBL604266 IC50 = 13300.0 nM 4.88
CHEMBL594018 IC50 = 13300.0 nM 4.88
CHEMBL607535 MEISOINDIGO IC50 = 18300.0 nM 4.74
CHEMBL594032 IC50 = 19000.0 nM 4.72
CHEMBL594713 IC50 = 19900.0 nM 4.70
CHEMBL515155 ISOINDIGO IC50 = 28900.0 nM 4.54
CHEMBL594849 IC50 > 20000.0 nM -
CHEMBL594611 IC50 > 20000.0 nM -
CHEMBL595210 IC50 > 30000.0 nM -
CHEMBL608404 IC50 > 30000.0 nM -