Assay Detail
Binding
CHEMBL1069456
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Inhibition of human recombinant SIRT2 by Flour de Lys assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.72 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224864 | — | — | 1 | 5.45 |
| CHEMBL490905 | — | — | 1 | 5.03 |
| CHEMBL596656 | — | — | 1 | 4.72 |
| CHEMBL596655 | — | — | 1 | 4.65 |
| CHEMBL597845 | SALERMIDE | — | 1 | 4.60 |
| CHEMBL372375 | — | — | 1 | 4.52 |
| CHEMBL200762 | — | — | 1 | 4.46 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.34 |
| CHEMBL86537 | SPLITOMICIN | — | 1 | - |
| CHEMBL596657 | — | — | 1 | - |
| CHEMBL611665 | — | — | 1 | - |
| CHEMBL597477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224864 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL490905 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL596656 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL596655 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL597845 | SALERMIDE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL372375 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL200762 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 45900.0 | nM | 4.34 |
| CHEMBL86537 | SPLITOMICIN | IC50 | = | 112900.0 | nM | - |
| CHEMBL596657 | — | IC50 | = | 191200.0 | nM | - |
| CHEMBL611665 | — | IC50 | = | 243600.0 | nM | - |
| CHEMBL597477 | — | IC50 | > | 10000.0 | nM | - |