Assay Detail
Binding
CHEMBL1069507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiprogestagenic activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.23 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 10.30 |
| CHEMBL1608 | DESMETHYLMIFEPRISTONE | — | 1 | 9.77 |
| CHEMBL452860 | — | — | 1 | 9.36 |
| CHEMBL453382 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1608 | DESMETHYLMIFEPRISTONE | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL452860 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL453382 | — | IC50 | = | 34.0 | nM | 7.47 |