Assay Detail
Functional
CHEMBL1069510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KBM5 cells harboring wild type Bcr-Abl after 72 hrs by MTS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBM5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.85 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 7.99 |
| CHEMBL604909 | — | — | 1 | 7.74 |
| CHEMBL599250 | — | — | 1 | 7.73 |
| CHEMBL596792 | — | — | 1 | 7.72 |
| CHEMBL603470 | — | — | 1 | 7.57 |
| CHEMBL597807 | — | — | 1 | 7.49 |
| CHEMBL597806 | — | — | 1 | 7.33 |
| CHEMBL599862 | — | — | 1 | 7.29 |
| CHEMBL597404 | — | — | 1 | 7.28 |
| CHEMBL598018 | — | — | 1 | 7.11 |
| CHEMBL589202 | — | — | 1 | 6.53 |
| CHEMBL597604 | — | — | 1 | 6.49 |
| CHEMBL603883 | — | — | 1 | 6.46 |
| CHEMBL598641 | — | — | 1 | 6.30 |
| CHEMBL598640 | — | — | 1 | 6.11 |
| CHEMBL603683 | — | — | 1 | 5.55 |
| CHEMBL592716 | — | — | 1 | 5.30 |
| CHEMBL589248 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL604909 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL599250 | — | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL596792 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL603470 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL597807 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL597806 | — | IC50 | = | 46.7 | nM | 7.33 |
| CHEMBL599862 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL597404 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL598018 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL589202 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL597604 | — | IC50 | = | 327.1 | nM | 6.49 |
| CHEMBL603883 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL598641 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL598640 | — | IC50 | = | 774.0 | nM | 6.11 |
| CHEMBL603683 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL592716 | — | IC50 | = | 5020.0 | nM | 5.30 |
| CHEMBL589248 | — | IC50 | = | 5420.0 | nM | 5.27 |