Assay Detail
ADMET
CHEMBL1069512
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Cytotoxicity against MEF after 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | MEF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.98 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 5.04 |
| CHEMBL604909 | — | — | 1 | 4.98 |
| CHEMBL596792 | — | — | 1 | 4.96 |
| CHEMBL597807 | — | — | 1 | 4.96 |
| CHEMBL597404 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL604909 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL596792 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL597807 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL597404 | — | IC50 | = | 11500.0 | nM | 4.94 |