Assay Detail
Binding
CHEMBL1069537
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Inhibition of human AChE by modified Ellman's spectrophotometric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.16 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1025 | ISOFLUROPHATE | 4.0 | 1 | 6.92 |
| CHEMBL590031 | — | — | 1 | 5.52 |
| CHEMBL592857 | — | — | 1 | 5.30 |
| CHEMBL604255 | — | — | 1 | 5.22 |
| CHEMBL592624 | — | — | 1 | 5.16 |
| CHEMBL592433 | — | — | 1 | 4.52 |
| CHEMBL606034 | — | — | 1 | 4.46 |
| CHEMBL591470 | — | — | 1 | 4.16 |
| CHEMBL592856 | — | — | 1 | - |
| CHEMBL591469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1025 | ISOFLUROPHATE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL590031 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL592857 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL604255 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL592624 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL592433 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL606034 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL591470 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL592856 | — | IC50 | = | 600000.0 | nM | - |
| CHEMBL591469 | — | IC50 | > | 1000000.0 | nM | - |