Assay Detail
Binding
CHEMBL1069538
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Inhibition of human AChE assessed as equilibrium binding by modified Ellman's spectrophotometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.65 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1025 | ISOFLUROPHATE | 4.0 | 1 | 5.22 |
| CHEMBL590031 | — | — | 1 | 4.62 |
| CHEMBL592624 | — | — | 1 | 4.12 |
| CHEMBL592433 | — | — | 1 | - |
| CHEMBL592857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1025 | ISOFLUROPHATE | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL590031 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL592624 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL592433 | — | Ki | = | 140000.0 | nM | - |
| CHEMBL592857 | — | Ki | = | 310000.0 | nM | - |