Assay Detail
Functional
CHEMBL1069864
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production by EIA
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.92 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595838 | — | — | 1 | 6.21 |
| CHEMBL595153 | — | — | 1 | 6.08 |
| CHEMBL603856 | — | — | 1 | 5.57 |
| CHEMBL595596 | — | — | 1 | 5.57 |
| CHEMBL609572 | — | — | 1 | 5.45 |
| CHEMBL593268 | — | — | 1 | 5.36 |
| CHEMBL603439 | — | — | 1 | 5.33 |
| CHEMBL7162 | NS-398 | — | 1 | 5.32 |
| CHEMBL595852 | — | — | 1 | 5.24 |
| CHEMBL603434 | — | — | 1 | 5.15 |
| CHEMBL595821 | — | — | 1 | 5.10 |
| CHEMBL610196 | — | — | 1 | 5.09 |
| CHEMBL595627 | — | — | 1 | 5.00 |
| CHEMBL596084 | — | — | 1 | 4.97 |
| CHEMBL607807 | — | — | 1 | 4.90 |
| CHEMBL595595 | — | — | 1 | 4.86 |
| CHEMBL594009 | — | — | 1 | 4.81 |
| CHEMBL595837 | — | — | 1 | 4.67 |
| CHEMBL593500 | — | — | 1 | 4.62 |
| CHEMBL372944 | — | — | 1 | 4.60 |
| CHEMBL610488 | — | — | 1 | 4.59 |
| CHEMBL201949 | — | — | 1 | 4.55 |
| CHEMBL593501 | — | — | 1 | 4.52 |
| CHEMBL593769 | — | — | 1 | 4.43 |
| CHEMBL595857 | — | — | 1 | 4.34 |
| CHEMBL593502 | — | — | 1 | 4.16 |
| CHEMBL604678 | — | — | 1 | 4.15 |
| CHEMBL595853 | — | — | 1 | 4.11 |
| CHEMBL604690 | — | — | 1 | 4.01 |
| CHEMBL595384 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595838 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL595153 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL603856 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL595596 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL609572 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL593268 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL603439 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL7162 | NS-398 | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL595852 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL603434 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL595821 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL610196 | — | IC50 | = | 8190.0 | nM | 5.09 |
| CHEMBL595627 | — | IC50 | = | 9950.0 | nM | 5.00 |
| CHEMBL596084 | — | IC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL607807 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL595595 | — | IC50 | = | 13830.0 | nM | 4.86 |
| CHEMBL594009 | — | IC50 | = | 15420.0 | nM | 4.81 |
| CHEMBL595837 | — | IC50 | = | 21520.0 | nM | 4.67 |
| CHEMBL593500 | — | IC50 | = | 23750.0 | nM | 4.62 |
| CHEMBL372944 | — | IC50 | = | 25080.0 | nM | 4.60 |
| CHEMBL610488 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL201949 | — | IC50 | = | 27940.0 | nM | 4.55 |
| CHEMBL593501 | — | IC50 | = | 30460.0 | nM | 4.52 |
| CHEMBL593769 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL595857 | — | IC50 | = | 45200.0 | nM | 4.34 |
| CHEMBL593502 | — | IC50 | = | 68750.0 | nM | 4.16 |
| CHEMBL604678 | — | IC50 | = | 71290.0 | nM | 4.15 |
| CHEMBL595853 | — | IC50 | = | 78480.0 | nM | 4.11 |
| CHEMBL604690 | — | IC50 | = | 98120.0 | nM | 4.01 |
| CHEMBL595384 | — | IC50 | - | — | - | |
| CHEMBL595851 | — | IC50 | - | — | - | |
| CHEMBL202135 | — | IC50 | = | 131530.0 | nM | - |