Assay Detail
Binding
CHEMBL1070134
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Inhibition of IKK-beta by tome resolved fluorescence assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of IKK-beta: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.12 | 7.75 |
| INH | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602534 | — | — | 1 | 7.75 |
| CHEMBL608154 | — | — | 1 | 7.35 |
| CHEMBL129857 | AS-602868 | 1.0 | 1 | 7.17 |
| CHEMBL79004 | — | — | 1 | 6.82 |
| CHEMBL249697 | BMS-345541 | — | 1 | 6.52 |
| CHEMBL228563 | — | — | 1 | - |
| CHEMBL228397 | — | — | 1 | - |
| CHEMBL424 | SALICYLIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602534 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL608154 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL129857 | AS-602868 | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL79004 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL249697 | BMS-345541 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL228563 | — | INH | = | 14.0 | uM | - |
| CHEMBL228397 | — | INH | = | 4.7 | uM | - |
| CHEMBL424 | SALICYLIC ACID | INH | > | 1000.0 | uM | - |