Assay Detail
Binding
CHEMBL1070691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.53 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596014 | — | — | 1 | 7.82 |
| CHEMBL596042 | — | — | 1 | 7.24 |
| CHEMBL606630 | — | — | 1 | 6.97 |
| CHEMBL594625 | — | — | 1 | 6.91 |
| CHEMBL596460 | — | — | 1 | 6.79 |
| CHEMBL200732 | — | — | 1 | 6.65 |
| CHEMBL522152 | — | — | 1 | 6.32 |
| CHEMBL603424 | — | — | 1 | 5.80 |
| CHEMBL119709 | IB-MECA | — | 1 | 5.54 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596014 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL596042 | — | Ki | = | 57.6 | nM | 7.24 |
| CHEMBL606630 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL594625 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL596460 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL200732 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL522152 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL603424 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL119709 | IB-MECA | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 5360.0 | nM | 5.27 |