Assay Detail
Binding
CHEMBL1070752
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Inhibition of TIE2 after 80 mins by radiometric protein kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.60 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606168 | — | — | 1 | 5.80 |
| CHEMBL605957 | — | — | 1 | 5.63 |
| CHEMBL201511 | MALEIMIDE | — | 1 | 5.58 |
| CHEMBL597492 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606168 | — | IC50 | = | 1567.0 | nM | 5.80 |
| CHEMBL605957 | — | IC50 | = | 2367.0 | nM | 5.63 |
| CHEMBL201511 | MALEIMIDE | IC50 | = | 2633.0 | nM | 5.58 |
| CHEMBL597492 | — | IC50 | = | 3961.0 | nM | 5.40 |