Assay Detail
Functional
CHEMBL1071663
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Inhibition of thrombin-induced pig platelet aggregation measured for 5 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.91 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL600208 | — | — | 1 | 8.07 |
| CHEMBL603466 | — | — | 1 | 8.05 |
| CHEMBL601451 | — | — | 1 | 8.05 |
| CHEMBL601450 | — | — | 1 | 8.04 |
| CHEMBL577670 | — | — | 1 | 8.04 |
| CHEMBL607582 | — | — | 1 | 8.03 |
| CHEMBL597760 | — | — | 1 | 8.02 |
| CHEMBL598193 | — | — | 1 | 8.02 |
| CHEMBL600207 | — | — | 1 | 8.01 |
| CHEMBL597565 | — | — | 1 | 8.01 |
| CHEMBL605151 | — | — | 1 | 8.00 |
| CHEMBL597566 | — | — | 1 | 8.00 |
| CHEMBL599814 | — | — | 1 | 8.00 |
| CHEMBL604951 | — | — | 1 | 8.00 |
| CHEMBL603490 | — | — | 1 | 7.99 |
| CHEMBL598192 | — | — | 1 | 7.99 |
| CHEMBL585819 | — | — | 1 | 7.97 |
| CHEMBL598408 | — | — | 1 | 7.96 |
| CHEMBL2372440 | — | — | 1 | 7.95 |
| CHEMBL600830 | — | — | 1 | 7.95 |
| CHEMBL447576 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL600208 | — | IC50 | = | 8.43 | nM | 8.07 |
| CHEMBL603466 | — | IC50 | = | 8.87 | nM | 8.05 |
| CHEMBL601451 | — | IC50 | = | 8.98 | nM | 8.05 |
| CHEMBL601450 | — | IC50 | = | 9.13 | nM | 8.04 |
| CHEMBL577670 | — | IC50 | = | 9.18 | nM | 8.04 |
| CHEMBL607582 | — | IC50 | = | 9.25 | nM | 8.03 |
| CHEMBL597760 | — | IC50 | = | 9.48 | nM | 8.02 |
| CHEMBL598193 | — | IC50 | = | 9.64 | nM | 8.02 |
| CHEMBL600207 | — | IC50 | = | 9.84 | nM | 8.01 |
| CHEMBL597565 | — | IC50 | = | 9.87 | nM | 8.01 |
| CHEMBL605151 | — | IC50 | = | 10.01 | nM | 8.00 |
| CHEMBL597566 | — | IC50 | = | 9.99 | nM | 8.00 |
| CHEMBL599814 | — | IC50 | = | 10.02 | nM | 8.00 |
| CHEMBL604951 | — | IC50 | = | 10.04 | nM | 8.00 |
| CHEMBL603490 | — | IC50 | = | 10.24 | nM | 7.99 |
| CHEMBL598192 | — | IC50 | = | 10.27 | nM | 7.99 |
| CHEMBL585819 | — | IC50 | = | 10.64 | nM | 7.97 |
| CHEMBL598408 | — | IC50 | = | 10.83 | nM | 7.96 |
| CHEMBL2372440 | — | IC50 | = | 11.35 | nM | 7.95 |
| CHEMBL600830 | — | IC50 | = | 11.12 | nM | 7.95 |
| CHEMBL447576 | — | IC50 | = | 881.0 | nM | 6.05 |