Compound Detail
CHEMBL597566
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL597566 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | KHUVQNFBAHNYDO-ULQDDVLXSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
439.6
MW (Da)
1.34
ALogP
6
HBA
3
HBD
112.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet CHEMBL4296519 | IC50 | 8.47 | 8.2175 | 3.4 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet | IC50 | = | 3.42 | nM | 8.47 | Inhibition of adenosine diphosphate-induced pig platelet aggregation measured fo... | 20122838 |
| Platelet | IC50 | = | 4.91 | nM | 8.31 | Inhibition of platelet activating factor-induced pig platelet aggregation measur... | 20122838 |
| Platelet | IC50 | = | 8.19 | nM | 8.09 | Inhibition of arachidonic acid-induced pig platelet aggregation measured for 5 m... | 20122838 |
| Platelet | IC50 | = | 9.99 | nM | 8.0 | Inhibition of thrombin-induced pig platelet aggregation measured for 5 mins | 20122838 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20122838 | 10.1016/j.bmc.2010.01.009 | Platelet | 4 |
| 20122838 | 10.1016/j.bmc.2010.01.009 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine