Assay Detail
Binding
CHEMBL1072161
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Inhibition of EGFR autophosphorylation in human A431 cells after 8 hrs by Western blot
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.91 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598007 | — | — | 1 | 7.36 |
| CHEMBL2021576 | — | — | 1 | 7.17 |
| CHEMBL597402 | — | — | 1 | 7.11 |
| CHEMBL2021575 | — | — | 1 | 6.84 |
| CHEMBL285063 | — | — | 1 | 6.82 |
| CHEMBL604914 | — | — | 1 | 6.54 |
| CHEMBL597200 | — | — | 1 | 6.54 |
| CHEMBL606403 | — | — | 1 | - |
| CHEMBL599047 | — | — | 1 | - |
| CHEMBL603266 | — | — | 1 | - |
| CHEMBL592617 | — | — | 1 | - |
| CHEMBL599863 | — | — | 1 | - |
| CHEMBL52765 | — | — | 1 | - |
| CHEMBL599251 | — | — | 1 | - |
| CHEMBL599453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598007 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2021576 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL597402 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2021575 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL285063 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL604914 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL597200 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL606403 | — | IC50 | - | — | - | |
| CHEMBL599047 | — | IC50 | - | — | - | |
| CHEMBL603266 | — | IC50 | - | — | - | |
| CHEMBL592617 | — | IC50 | - | — | - | |
| CHEMBL599863 | — | IC50 | - | — | - | |
| CHEMBL52765 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL599251 | — | IC50 | - | — | - | |
| CHEMBL599453 | — | IC50 | - | — | - |