Assay Detail
Functional
CHEMBL1072163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.29 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285063 | — | — | 1 | 6.21 |
| CHEMBL598007 | — | — | 1 | 5.76 |
| CHEMBL2021575 | — | — | 1 | 5.17 |
| CHEMBL597200 | — | — | 1 | 5.11 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.08 |
| CHEMBL597402 | — | — | 1 | 4.96 |
| CHEMBL52765 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285063 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL598007 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL2021575 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL597200 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL939 | GEFITINIB | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL597402 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL52765 | — | IC50 | = | 19500.0 | nM | 4.71 |