Assay Detail
Binding
CHEMBL1072175
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Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat hippocampus
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.34 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL599612 | — | — | 1 | 7.55 |
| CHEMBL161765 | — | — | 1 | 7.37 |
| CHEMBL158285 | — | — | 1 | 6.88 |
| CHEMBL597981 | — | — | 1 | 6.29 |
| CHEMBL609323 | — | — | 1 | 6.17 |
| CHEMBL597356 | — | — | 1 | 6.04 |
| CHEMBL597357 | — | — | 1 | 6.03 |
| CHEMBL599423 | — | — | 1 | 5.63 |
| CHEMBL589524 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL599612 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL161765 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL158285 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL597981 | — | Ki | = | 516.0 | nM | 6.29 |
| CHEMBL609323 | — | Ki | = | 676.0 | nM | 6.17 |
| CHEMBL597356 | — | Ki | = | 902.0 | nM | 6.04 |
| CHEMBL597357 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL599423 | — | Ki | = | 2350.0 | nM | 5.63 |
| CHEMBL589524 | — | Ki | = | 7220.0 | nM | 5.14 |