Assay Detail
Binding
CHEMBL1072745
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Inhibition of MAGL in mouse brain membrane
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576786 | — | — | 1 | 8.00 |
| CHEMBL603704 | — | — | 1 | 8.00 |
| CHEMBL602281 | — | — | 1 | 7.82 |
| CHEMBL606201 | — | — | 1 | 7.72 |
| CHEMBL604758 | — | — | 1 | 7.40 |
| CHEMBL601243 | — | — | 1 | 7.30 |
| CHEMBL600429 | — | — | 1 | 7.30 |
| CHEMBL597515 | — | — | 1 | 7.16 |
| CHEMBL604948 | — | — | 1 | 7.16 |
| CHEMBL599989 | — | — | 1 | 7.14 |
| CHEMBL597699 | — | — | 1 | 7.10 |
| CHEMBL602283 | — | — | 1 | 7.05 |
| CHEMBL601244 | — | — | 1 | 7.05 |
| CHEMBL591688 | — | — | 1 | 7.05 |
| CHEMBL603111 | — | — | 1 | 6.89 |
| CHEMBL602499 | — | — | 1 | 6.70 |
| CHEMBL603077 | — | — | 1 | 6.70 |
| CHEMBL601002 | — | — | 1 | 6.52 |
| CHEMBL600428 | — | — | 1 | 6.30 |
| CHEMBL599725 | — | — | 1 | 6.29 |
| CHEMBL599724 | — | — | 1 | 6.25 |
| CHEMBL602282 | — | — | 1 | 6.17 |
| CHEMBL602292 | — | — | 1 | 6.16 |
| CHEMBL597514 | — | — | 1 | 6.09 |
| CHEMBL597700 | — | — | 1 | 6.05 |
| CHEMBL599731 | — | — | 1 | 5.96 |
| CHEMBL599726 | — | — | 1 | 5.89 |
| CHEMBL602293 | — | — | 1 | 5.86 |
| CHEMBL602084 | — | — | 1 | 5.82 |
| CHEMBL605004 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576786 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL603704 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL602281 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL606201 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL604758 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL601243 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL600429 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL597515 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL604948 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL599989 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL597699 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL602283 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL601244 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL591688 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL603111 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL602499 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL603077 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL601002 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL600428 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL599725 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL599724 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL602282 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL602292 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL597514 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL597700 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL599731 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL599726 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL602293 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL602084 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL605004 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL599990 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL601003 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL602936 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL601892 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL601893 | — | IC50 | > | 50000.0 | nM | - |