Assay Detail
Binding
CHEMBL1072820
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Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation counting
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SNB-19 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.23 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL600474 | — | — | 1 | 4.28 |
| CHEMBL863 | CYSTEINE | 4.0 | 1 | 4.23 |
| CHEMBL601837 | — | — | 1 | 4.22 |
| CHEMBL604574 | — | — | 1 | 4.19 |
| CHEMBL606915 | — | — | 1 | - |
| CHEMBL591770 | — | — | 1 | - |
| CHEMBL590556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL600474 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL863 | CYSTEINE | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL601837 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL604574 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL606915 | — | Ki | = | 113000.0 | nM | - |
| CHEMBL591770 | — | Ki | = | 117000.0 | nM | - |
| CHEMBL590556 | — | Ki | = | 147000.0 | nM | - |