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Assay Detail

CHEMBL1072971

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Antiproliferative activity against human Detroit 551 cells by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Detroit 551
Confidence 1 — Organism
Curated By Autocuration

Target

Detroit 551 (CHEMBL614284)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and antiproliferative evaluation of certain indolo[3,2-c]quinoline derivatives.
Lu CM, Chen YL, Chen HL, Chen CA, Lu PJ, Yang CN, Tzeng CC.
Bioorg Med Chem (2010) 18 : 1948 -1957
PubMed 20171108 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.33 5.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL597620 1 5.76
CHEMBL592704 1 5.70
CHEMBL592851 1 5.67
CHEMBL599054 1 5.66
CHEMBL597419 1 5.66
CHEMBL596604 1 5.58
CHEMBL598855 1 5.50
CHEMBL609310 1 5.41
CHEMBL599640 1 5.37
CHEMBL606049 1 4.71
CHEMBL596798 1 4.59
CHEMBL596799 1 4.37
CHEMBL597613 1 -
CHEMBL605116 1 -
CHEMBL606402 1 -
CHEMBL597621 1 -
CHEMBL53463 DOXORUBICIN 4.0 1 -
CHEMBL605320 1 -
CHEMBL599430 1 -
CHEMBL598620 1 -
CHEMBL603250 1 -
CHEMBL592473 1 -
CHEMBL592500 1 -
CHEMBL603619 1 -
CHEMBL596605 1 -
CHEMBL598827 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL597620 IC50 = 1740.0 nM 5.76
CHEMBL592704 IC50 = 1980.0 nM 5.70
CHEMBL592851 IC50 = 2140.0 nM 5.67
CHEMBL599054 IC50 = 2210.0 nM 5.66
CHEMBL597419 IC50 = 2180.0 nM 5.66
CHEMBL596604 IC50 = 2600.0 nM 5.58
CHEMBL598855 IC50 = 3150.0 nM 5.50
CHEMBL609310 IC50 = 3880.0 nM 5.41
CHEMBL599640 IC50 = 4300.0 nM 5.37
CHEMBL606049 IC50 = 19320.0 nM 4.71
CHEMBL596798 IC50 = 25430.0 nM 4.59
CHEMBL596799 IC50 = 42540.0 nM 4.37
CHEMBL597613 IC50 - -
CHEMBL605116 IC50 - -
CHEMBL606402 IC50 - -
CHEMBL597621 IC50 - -
CHEMBL53463 DOXORUBICIN IC50 - -
CHEMBL605320 IC50 - -
CHEMBL599430 IC50 - -
CHEMBL598620 IC50 - -
CHEMBL603250 IC50 - -
CHEMBL592473 IC50 - -
CHEMBL592500 IC50 - -
CHEMBL603619 IC50 - -
CHEMBL596605 IC50 - -
CHEMBL598827 IC50 - -