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Target Snapshot

CHEMBL614284 Target Snapshot

Detroit 551 · CELL-LINE · Homo sapiens

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287Compounds
33Assays
0Approved Drugs
227.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Detroit 551 as ChEMBL target CHEMBL614284. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Detroit 551
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL614284
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Detroit 551 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameDetroit 551
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDetroit 551
UniProt AccessionN/A

Detroit 551

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Detroit 551.

Review nameDetroit 551
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50227.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 6.0 IC50 990.0 Preclinical
CHEMBL597620 5.76 IC50 1740.0 Preclinical
CHEMBL1197989 5.7 IC50 1980.0 Preclinical
CHEMBL592704 5.7 IC50 1980.0 Preclinical
CHEMBL3585507 5.69 IC50 2050.0 Preclinical
CHEMBL592851 5.67 IC50 2140.0 Preclinical
CHEMBL597419 5.66 IC50 2180.0 Preclinical
CHEMBL599054 5.66 IC50 2210.0 Preclinical
CHEMBL3585499 5.6 IC50 2530.0 Preclinical
CHEMBL3585494 5.59 IC50 2550.0 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
15
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

33
Total Assays
48
Tested Compounds
4
Assay Types
ADME — 16 assays, 48 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 48 4.6
Functional — 8 assays, 23 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 23 5.3
Unassigned — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 0 —
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine