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Compound Detail

CHEMBL3585499

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CNCCNCCC(=O)N1CCN(c2nc3ccccc3c3c2-c2ccc(OC)cc2C3=O)CC1

Basic Information

ChEMBL ID CHEMBL3585499
Phase Preclinical
Structure Type MOL
InChI Key UMJHFSPEFHMBSS-UHFFFAOYSA-N
7
Targets
8
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

473.6
MW (Da)
2.30
ALogP
7
HBA
2
HBD
86.8
PSA (Ų)
0.38
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H31N5O3
MW 473.58
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.46

Activity Summary

IC50 8 meas. best 5.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Detroit 551
CHEMBL614284
IC50 5.6 5.6 2530.0 1
HeLa
CHEMBL399
IC50 5.32 5.32 4780.0 1
AGS
CHEMBL613860
IC50 5.31 5.31 4940.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.29 5.22 5080.0 2
NCI-H1299
CHEMBL612255
IC50 5.25 5.25 5650.0 1
MDA-MB-231
CHEMBL400
IC50 5.13 5.13 7440.0 1
SAS
CHEMBL1075569
IC50 5.06 5.06 8800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C4MD00133H NON-PROTEIN TARGET 2
- 10.1039/C4MD00133H Detroit 551 1
- 10.1039/C4MD00133H NCI-H1299 1
- 10.1039/C4MD00133H MDA-MB-231 1
- 10.1039/C4MD00133H AGS 1
- 10.1039/C4MD00133H SAS 1
- 10.1039/C4MD00133H HeLa 1

Data from ChEMBL 36 via Core Engine