Assay Detail
Functional
CHEMBL3588533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative evaluation of 9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinoline-11-one derivatives. Part 4
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.38 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.75 |
| CHEMBL3585506 | — | — | 1 | 6.27 |
| CHEMBL3585507 | — | — | 1 | 6.01 |
| CHEMBL3585496 | — | — | 1 | 5.72 |
| CHEMBL3585490 | — | — | 1 | 5.69 |
| CHEMBL409424 | — | — | 1 | 5.63 |
| CHEMBL3585505 | — | — | 1 | 5.61 |
| CHEMBL3585498 | — | — | 1 | 5.50 |
| CHEMBL3585504 | — | — | 1 | 5.33 |
| CHEMBL3585501 | — | — | 1 | 5.33 |
| CHEMBL3585491 | — | — | 1 | 5.32 |
| CHEMBL3585499 | — | — | 1 | 5.32 |
| CHEMBL3585500 | — | — | 1 | 5.26 |
| CHEMBL3585492 | — | — | 1 | 5.09 |
| CHEMBL3585493 | — | — | 1 | 4.97 |
| CHEMBL3585503 | — | — | 1 | 4.97 |
| CHEMBL3585497 | — | — | 1 | 4.93 |
| CHEMBL3585350 | — | — | 1 | 4.93 |
| CHEMBL3585502 | — | — | 1 | 4.84 |
| CHEMBL408668 | — | — | 1 | 4.82 |
| CHEMBL3585495 | — | — | 1 | 4.74 |
| CHEMBL3585494 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3585506 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3585507 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL3585496 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3585490 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL409424 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL3585505 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL3585498 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL3585504 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL3585501 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL3585491 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL3585499 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL3585500 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL3585492 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL3585493 | — | IC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL3585503 | — | IC50 | = | 10660.0 | nM | 4.97 |
| CHEMBL3585497 | — | IC50 | = | 11660.0 | nM | 4.93 |
| CHEMBL3585350 | — | IC50 | = | 11840.0 | nM | 4.93 |
| CHEMBL3585502 | — | IC50 | = | 14310.0 | nM | 4.84 |
| CHEMBL408668 | — | IC50 | = | 15180.0 | nM | 4.82 |
| CHEMBL3585495 | — | IC50 | = | 18020.0 | nM | 4.74 |
| CHEMBL3585494 | — | IC50 | > | 30000.0 | nM | - |