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Compound Detail

CHEMBL3585506

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COc1ccc2c(c1)/C(=N\OCC1CO1)c1c-2c(N2CCN(CC3CO3)CC2)nc2ccccc12

Basic Information

ChEMBL ID CHEMBL3585506
Phase Preclinical
Structure Type MOL
InChI Key RNVKVBSOGCRCSI-PBBVDAKRSA-N
7
Targets
8
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

472.6
MW (Da)
2.91
ALogP
8
HBA
0
HBD
75.2
PSA (Ų)
0.30
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H28N4O4
MW 472.55
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.64

Activity Summary

IC50 8 meas. best 6.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HeLa
CHEMBL399
IC50 6.27 6.27 540.0 1
MDA-MB-231
CHEMBL400
IC50 6.1 6.1 790.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 6.0 5.53 990.0 2
NCI-H1299
CHEMBL612255
IC50 5.93 5.93 1180.0 1
SAS
CHEMBL1075569
IC50 5.21 5.21 6200.0 1
Detroit 551
CHEMBL614284
IC50 5.1 5.1 7950.0 1
AGS
CHEMBL613860
IC50 5.06 5.06 8760.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C4MD00133H NCI-H1299 13
- 10.1039/C4MD00133H Molecular identity unknown 5
- 10.1039/C4MD00133H NON-PROTEIN TARGET 2
- 10.1039/C4MD00133H Detroit 551 1
- 10.1039/C4MD00133H MDA-MB-231 1
- 10.1039/C4MD00133H AGS 1
- 10.1039/C4MD00133H SAS 1
- 10.1039/C4MD00133H Nucleic Acid 1
- 10.1039/C4MD00133H HeLa 1

Data from ChEMBL 36 via Core Engine