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Compound Detail

CHEMBL3585498

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COc1ccc2c(c1)C(=O)c1c-2c(N2CCN(C(=O)CCNCCO)CC2)nc2ccccc12

Basic Information

ChEMBL ID CHEMBL3585498
Phase Preclinical
Structure Type MOL
InChI Key CBQBVWNXIQFQIK-UHFFFAOYSA-N
7
Targets
8
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

460.5
MW (Da)
2.08
ALogP
7
HBA
2
HBD
95.0
PSA (Ų)
0.41
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28N4O4
MW 460.53
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.52

Activity Summary

IC50 8 meas. best 5.69

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.69 5.52 2030.0 2
HeLa
CHEMBL399
IC50 5.5 5.5 3130.0 1
AGS
CHEMBL613860
IC50 5.43 5.43 3670.0 1
NCI-H1299
CHEMBL612255
IC50 5.25 5.25 5670.0 1
MDA-MB-231
CHEMBL400
IC50 5.22 5.22 6080.0 1
Detroit 551
CHEMBL614284
IC50 5.08 5.08 8380.0 1
SAS
CHEMBL1075569
IC50 5.04 5.04 9100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C4MD00133H NON-PROTEIN TARGET 2
- 10.1039/C4MD00133H Detroit 551 1
- 10.1039/C4MD00133H NCI-H1299 1
- 10.1039/C4MD00133H MDA-MB-231 1
- 10.1039/C4MD00133H AGS 1
- 10.1039/C4MD00133H SAS 1
- 10.1039/C4MD00133H HeLa 1

Data from ChEMBL 36 via Core Engine