Assay Detail
Functional
CHEMBL1073156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed inhibition of viral-induced cytopathic effect after 5 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.24 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.05 |
| CHEMBL234401 | — | — | 1 | 8.66 |
| CHEMBL601219 | — | — | 1 | 8.22 |
| CHEMBL600615 | — | — | 1 | 8.09 |
| CHEMBL601007 | — | — | 1 | 8.01 |
| CHEMBL592877 | — | — | 1 | 7.82 |
| CHEMBL600411 | — | — | 1 | 7.58 |
| CHEMBL601866 | — | — | 1 | 7.46 |
| CHEMBL600170 | — | — | 1 | 7.34 |
| CHEMBL601867 | — | — | 1 | 7.20 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.14 |
| CHEMBL601006 | — | — | 1 | 6.92 |
| CHEMBL603275 | — | — | 1 | 6.89 |
| CHEMBL601868 | — | — | 1 | 6.51 |
| CHEMBL608269 | — | — | 1 | 6.30 |
| CHEMBL603276 | — | — | 1 | 6.00 |
| CHEMBL603270 | — | — | 1 | 5.72 |
| CHEMBL600198 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL234401 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL601219 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL600615 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL601007 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL592877 | — | EC50 | = | 15.1 | nM | 7.82 |
| CHEMBL600411 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL601866 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL600170 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL601867 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL601006 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL603275 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL601868 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL608269 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL603276 | — | EC50 | = | 1002.0 | nM | 6.00 |
| CHEMBL603270 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL600198 | — | EC50 | = | 3660.0 | nM | 5.44 |