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Assay Detail

CHEMBL1073712

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Functional
Antiviral activity against HIV1 NL4-3 infected in GFP expressing human CEM cells assessed as inhibition of viral infection measured after 9 days postinfection by microfluorometry
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols.
Chauthe SK, Bharate SB, Sabde S, Mitra D, Bhutani KK, Singh IP.
Bioorg Med Chem (2010) 18 : 2029 -2036
PubMed 20137956 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.51 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL577877 1 6.55
CHEMBL129 ZIDOVUDINE 4.0 1 5.98
CHEMBL578267 1 5.57
CHEMBL591220 1 5.47
CHEMBL597564 1 5.39
CHEMBL603489 1 5.22
CHEMBL601240 1 5.17
CHEMBL609163 1 4.73
CHEMBL451217 1 -
CHEMBL598794 1 -
CHEMBL601738 1 -
CHEMBL597363 1 -
CHEMBL578493 1 -
CHEMBL604093 1 -
CHEMBL601524 1 -
CHEMBL591221 1 -
CHEMBL600675 1 -
CHEMBL591222 1 -
CHEMBL598590 1 -
CHEMBL600023 1 -
CHEMBL591462 1 -
CHEMBL603110 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL577877 IC50 = 280.0 nM 6.55
CHEMBL129 ZIDOVUDINE IC50 = 1050.0 nM 5.98
CHEMBL578267 IC50 = 2710.0 nM 5.57
CHEMBL591220 IC50 = 3370.0 nM 5.47
CHEMBL597564 IC50 = 4090.0 nM 5.39
CHEMBL603489 IC50 = 6060.0 nM 5.22
CHEMBL601240 IC50 = 6750.0 nM 5.17
CHEMBL609163 IC50 = 18590.0 nM 4.73
CHEMBL451217 IC50 - -
CHEMBL598794 IC50 - -
CHEMBL601738 IC50 - -
CHEMBL597363 IC50 - -
CHEMBL578493 IC50 - -
CHEMBL604093 IC50 - -
CHEMBL601524 IC50 - -
CHEMBL591221 IC50 - -
CHEMBL600675 IC50 - -
CHEMBL591222 IC50 - -
CHEMBL598590 IC50 - -
CHEMBL600023 IC50 - -
CHEMBL591462 IC50 - -
CHEMBL603110 IC50 - -