Assay Detail
Binding
CHEMBL1074028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat Y5 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.62 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594163 | — | — | 1 | 8.77 |
| CHEMBL595573 | MK-0557 | 3.0 | 1 | 8.68 |
| CHEMBL595790 | — | — | 1 | 8.68 |
| CHEMBL595560 | — | — | 1 | 8.66 |
| CHEMBL594156 | — | — | 1 | 8.60 |
| CHEMBL595120 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594163 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL595573 | MK-0557 | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL595790 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL595560 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL594156 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL595120 | — | IC50 | = | 4.7 | nM | 8.33 |