Assay Detail
Binding
CHEMBL1074153
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Inhibition of human liver recombinant FBPase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.70 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589266 | — | — | 1 | 9.00 |
| CHEMBL597891 | — | — | 1 | 8.70 |
| CHEMBL597692 | — | — | 1 | 8.52 |
| CHEMBL597484 | — | — | 1 | 8.10 |
| CHEMBL597282 | — | — | 1 | 8.10 |
| CHEMBL592639 | — | — | 1 | 8.05 |
| CHEMBL597691 | — | — | 1 | 8.05 |
| CHEMBL605956 | — | — | 1 | 8.05 |
| CHEMBL609616 | — | — | 1 | 8.00 |
| CHEMBL495498 | MB-05032 | 2.0 | 1 | 8.00 |
| CHEMBL592391 | — | — | 1 | 7.96 |
| CHEMBL592390 | — | — | 1 | 7.92 |
| CHEMBL597483 | — | — | 1 | 7.82 |
| CHEMBL606385 | — | — | 1 | 7.55 |
| CHEMBL603871 | — | — | 1 | 7.40 |
| CHEMBL567704 | — | — | 1 | 6.91 |
| CHEMBL597068 | — | — | 1 | 6.11 |
| CHEMBL596870 | — | — | 1 | 6.04 |
| CHEMBL603409 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589266 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL597891 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL597692 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL597484 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL597282 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL592639 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL597691 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL605956 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL609616 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL495498 | MB-05032 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL592391 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL592390 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL597483 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL606385 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL603871 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL567704 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL597068 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL596870 | — | IC50 | = | 908.0 | nM | 6.04 |
| CHEMBL603409 | — | IC50 | = | 995.0 | nM | 6.00 |