Assay Detail
Binding
CHEMBL1074290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from adenosine A1 receptor in rat brain cortical membrane in presence of 100 uM GTP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.33 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592679 | — | — | 1 | 7.65 |
| CHEMBL591710 | — | — | 1 | 7.54 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592679 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL591710 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 154.0 | nM | 6.81 |