Assay Detail
Functional
CHEMBL1074445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Analgesic activity in po dosed Sprague-Dawley rat assessed as inhibition of carrageenan-induced mechanical hyperalgesia
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 1 | - | - |
| ED50 | 1 | - | - |
| EC50 | 1 | 6.60 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597997 | — | — | 3 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597997 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL597997 | — | Activity | - | — | - | |
| CHEMBL597997 | — | ED50 | = | 0.36 | mg.kg-1 | - |