Assay Detail
Binding
CHEMBL1074685
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Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.90 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590111 | — | — | 1 | 7.52 |
| CHEMBL590359 | — | — | 1 | 7.52 |
| CHEMBL589863 | — | — | 1 | 7.40 |
| CHEMBL590597 | — | — | 1 | 7.40 |
| CHEMBL590839 | — | — | 1 | 7.30 |
| CHEMBL601691 | — | — | 1 | 7.30 |
| CHEMBL590361 | — | — | 1 | 7.22 |
| CHEMBL593282 | — | — | 1 | 7.16 |
| CHEMBL589865 | — | — | 1 | 7.16 |
| CHEMBL610462 | — | — | 1 | 7.10 |
| CHEMBL595529 | — | — | 1 | 7.05 |
| CHEMBL594444 | — | — | 1 | 7.05 |
| CHEMBL611631 | — | — | 1 | 7.05 |
| CHEMBL589137 | — | — | 1 | 7.00 |
| CHEMBL595150 | — | — | 1 | 7.00 |
| CHEMBL595149 | — | — | 1 | 6.96 |
| CHEMBL590360 | — | — | 1 | 6.92 |
| CHEMBL752 | ADENOSINE PHOSPHATE | 4.0 | 1 | 6.85 |
| CHEMBL589862 | — | — | 1 | 6.85 |
| CHEMBL589861 | — | — | 1 | 6.77 |
| CHEMBL594445 | — | — | 1 | 6.72 |
| CHEMBL590840 | — | — | 1 | 6.72 |
| CHEMBL585620 | — | — | 1 | 6.68 |
| CHEMBL608398 | — | — | 1 | 6.54 |
| CHEMBL585961 | — | — | 1 | 6.46 |
| CHEMBL594668 | — | — | 1 | 6.42 |
| CHEMBL595067 | — | — | 1 | 6.42 |
| CHEMBL595304 | — | — | 1 | 6.14 |
| CHEMBL607540 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590111 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL590359 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL589863 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL590597 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL590839 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL601691 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL590361 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL593282 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL589865 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL610462 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL595529 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL594444 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL611631 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL589137 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL595150 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL595149 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL590360 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL752 | ADENOSINE PHOSPHATE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL589862 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL589861 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL594445 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL590840 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL585620 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL608398 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL585961 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL594668 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL595067 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL595304 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL607540 | — | IC50 | = | 3500.0 | nM | 5.46 |