Assay Detail
Binding
CHEMBL1074776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rosiglitazone from rat liver mitochondrial mitoNEET by scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
CDGSH iron-sulfur domain-containing protein 1 (CHEMBL3308979) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.00 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602048 | — | — | 1 | 6.05 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.00 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602048 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 1100.0 | nM | 5.96 |