Assay Detail
Binding
CHEMBL1074787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Heart |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-dependent L-type calcium channel subunit alpha-1S (CHEMBL4108) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.86 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL599337 | — | — | 1 | 9.38 |
| CHEMBL592155 | — | — | 1 | 9.12 |
| CHEMBL599336 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL599337 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL592155 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL599336 | — | IC50 | = | 8.14 | nM | 8.09 |