Compound Detail
CHEMBL599337
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CCCCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1c1cccc([N+](=O)[O-])c1
Basic Information
| ChEMBL ID | CHEMBL599337 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GBUPAHJHIJULEM-IBGZPJMESA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
402.4
MW (Da)
3.74
ALogP
7
HBA
1
HBD
107.8
PSA (Ų)
0.31
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1S CHEMBL4108 | IC50 | 9.38 | 9.105 | 0.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1S | IC50 | = | 0.42 | nM | 9.38 | Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cardiac me... | 20064722 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | IC50 | = | 1.48 | nM | 8.83 | Displacement of [3H]nitrendipine from dihydropyridine receptor in rat cerebral c... | 20064722 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20064722 | 10.1016/j.bmcl.2009.12.104 | Voltage-dependent L-type calcium channel subunit alpha-1S | 2 |
Data from ChEMBL 36 via Core Engine