Assay Detail
Functional
CHEMBL1099680
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Vasorelaxant activity in 80 mM K+-depolarized guinea pig thoracic aortic strip assessed as inhibition of calcium-induced contraction
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.09 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 5.58 |
| CHEMBL1076181 | — | — | 1 | 5.29 |
| CHEMBL1076546 | — | — | 1 | 5.25 |
| CHEMBL213369 | — | — | 1 | 4.75 |
| CHEMBL214488 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1076181 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL1076546 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL213369 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL214488 | — | IC50 | = | 25100.0 | nM | 4.60 |