Assay Detail
Binding
CHEMBL1099688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of L-type calcium channel in Wistar rat cardiomyocytes assessed as inhibition of peak L-type barium current by whole cell patch clamp method
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.62 | 4.65 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1076181 | — | — | 1 | 4.65 |
| CHEMBL1076546 | — | — | 2 | 4.63 |
| CHEMBL212643 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1076181 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL1076546 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL212643 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL1076546 | — | Inhibition | - | % | - |